The results showed that LM (HR = 1.497 [1.170–2.113], p < 0.001), RFA of the primary site (HR = 1.550 [1.153–2.165], p < 0.001), surgery of the primary site (HR = 1.719 [1.288–2.630], p < 0.001), tumor max length (HR = 1.564 [1.166–2.138], p = 0.022), tumor number (HR = 1.610 [1.254–2.230], p < 0.001), AFP (HR = 1.581 [1.379–2.170], p = 0.018), clinically significant portal hypertension (CSPH) (HR = 1.691 [1.210–2.277], p = 0.037), PVTT (HR = 2.087 [1.726–2.612], p < 0.001), and drug usage's TKI+ICI (HR = 1.628 [1.316–2.267], p < 0.001) were significant predictors (Table 2). The gene discussed is AFP; the disease is portal hypertension.