While CRP cannot be said to directly mediate the relationship in this sample, adjusted regression analysis found that CRP was a significant, independent predictor of pain-type somatic symptoms (β = .12, p < .001), independent of anxiety score (β = .20, p < .001), depression score (β = .38, p < .001), and the interaction term anxiety∗depression (β = −.15, p < .001), indicating that CRP may underly pain-type somatic symptoms, independent of mental health symptoms in adolescence. The gene discussed is CRP; the disease is major depressive disorder.