Similar associations have been observed between serum and plasma CRP and IL-6, and somatic depression symptoms, including, appetite changes and sleep disturbances (Frank et al., 2021; Jokela et al., 2016; Moriarity et al., 2023), and somatic anxiety symptoms (plasma CRP; Duivis et al., 2013). The gene discussed is IL6; the disease is major depressive disorder.