It's also worth noting that based on the data available from the ALSPAC dataset, the current study included only one inflammatory marker, CRP, while other pro- and anti-inflammatory molecules (such as IL-6, TNF-α, sP-selectin) have been associated with both anxiety and/or depression (e.g. Frank et al., 2021) and somatic pain (e.g. Bai et al., 2014). This evidence concerns the gene TNF and depressive symptom measurement.