Thus, the DoRothEA and CARNIVAL analysis suggest a mechanistic hypothesis as to the signaling path through which tasquinimod treatment reverses the JAK2V617F‐induced deregulation of TFs starting with binding of the alarmins S100a8/S100a9 to Tlr4 regulating proliferation and apoptosis through Myc and E2f and suggesting a Myc‐Jag2‐Notch2 link that can be associated with remodeling of the tumor microenvironment.14 Here, TLR4 is linked to neoplasm.