KCNK5 and migraine disorder: Two pore-domain open rectifier channels, especially TRESK (12, 40, 41, 43, 77, 79, 80, 83, 119, 120, 135–147), TREK-1 (84, 119, 144, 145, 148) and TASK-2 (144, 145) have been shown to be involved in cortical spreading depression and migraine nociception.