The multivariate logistic regression analysis revealed that, after adjusting for age, gender, smoking history, drinking history, hypertension, diabetes, coronary heart disease, stroke, dyslipidemia, LDL-C, ALB, HCY, Cr, hs-CRP, and the use of antihypertensive, hypoglycemic, antiplatelet, and lipid-lowering medications, the UHR was independently associated with a moderate-to-severe PVS burden (odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.03–1.12, p < 0.001) (Table 2). This evidence concerns the gene CRP and stroke disorder.