The RCS analysis indicated that, after adjusting for age, gender, smoking history, drinking history, hypertension, diabetes, coronary heart disease, stroke, dyslipidemia, LDL-C, ALB, HCY, Cr, hs-CRP, and the use of antihypertensive, hypoglycemic, antiplatelet, and lipid-lowering drugs, a linear positive relationship was observed between UHR and the moderate-to-severe PVS burden (p = 0.002, P for non-linear test = 0.121) (Figure 2). Here, CRP is linked to stroke disorder.