Plasma protein profiling has revealed the presence of a heightened abundance of pro-inflammatory proteins, which include pigment epithelium-derived factor (PEDF), proteoglycan (PRG4), and fibronectin 1 (FN1), in the plasma of women prior to the diagnosis of gestational diabetes, suggesting that the inflammatory state was present long before the diagnosis of diabetes mellitus (47). The gene discussed is SERPINF1; the disease is gestational diabetes.