Anti-IgE exposure was associated with a significantly lower risk of mortality (aHR 0.48, 95% CI 0.40–0.58), congestive heart failure (aHR 0.79, 95% CI 0.65–0.95), peripheral artery disease (aHR 0.66, 95% CI 0.51–0.86), and stroke (aHR 0.54, 95% CI 0.36–0.81). The gene discussed is IGHE; the disease is peripheral arterial disease.