,31,32 In our case-control analysis with interaction terms, we observed that anti-IgE was associated with a higher risk of myocardial infarction, and both anti-IgE and anti-IL5 were associated with a higher risk of pulmonary embolism, and anti-IL5 with stroke, however, none of these associations were statistically significant. Here, IGHE is linked to pulmonary embolism.