There was no significant difference in the relative expression of RANK protein between the obesity group [(0.99 ± 0.08)] and the non-obesity group [(0.81 ± 0.27)] (T = 0.144, P = 0.701), while the expression of RANK gene was significantly different between the obesity group [(2.51 ± 1.29)] and the non-obesity group [(1.16 ± 0.62)] (T = −5.969, P < 0.001), as shown in Table 4 and Figure 1. This evidence concerns the gene TNFRSF11A and obesity due to melanocortin 4 receptor deficiency.