ALB and Hepatic fibrosis: Its increase strongly correlated with reductions in FIB-4 (coefficient = -0.081 per 1% increase), ALT (coefficient = -0.396 IU/L per 1% increase), AST (coefficient = -0.434 IU/L per 1% increase, Fig. S5A), and an ALB rise (coefficient = 0.0147 g/dl per 1% increase, Fig. S5B), indicating that improvements in liver fibrosis and inflammation are linked to the increase in Blautia.