In the European ancestry GWAS meta-analysis (n = 9 studies, 3,748 cases, and 1,861,536 controls), we identified eight genome-wide significant variants (Fig. 2 and Table 1), of which five (KLF15, HFE, HSD17B13, APOE, and MTARC1) have not previously been implicated in HCC at genome-wide statistical significance. This evidence concerns the gene KLF15 and hepatocellular carcinoma.