Of these, increasing levels of alanine transaminase (ALT), aspartate transaminase (AST), and gamma-glutamyl transferase (GGT) were associated with HCC (p <1.3x10-3 [0.05/39 tests]), but ALT and AST showed evidence of pleiotropy (Egger intercept p <0.05). The gene discussed is GPT; the disease is hepatocellular carcinoma.