Of these eight variants, three were associated with HCC: SERPINA1 rs28929474 (p = 5.5x10-7), MBOAT7 rs641738 (p = 1.5x10-4), and HLA-DQB1 rs9275224 (p = 6.3x10-3). This evidence concerns the gene SERPINA1 and hepatocellular carcinoma.