HFE and biliary tract cancer: There was no significant overlap between genetic effects on HCC and biliary tract cancer (r2 = -0.035, p = 0.42), with three exceptions, namely TERT, HFE, and APOE, which all had concordant effects on both HCC and biliary tract cancer (p = 0.004, 0.008, and 0.003, respectively, for association with biliary tract cancer) (Fig. 3C).