RNA-seq and m6A-seq analyses indicated that METTL3 regulates the expression of histone H2A family member X (H2AX) through m6A modification, affecting the PI3K/AKT and mitogen-activated protein kinase (MAPK) axes, which contribute to NSCLC resistance to carbon ion radiotherapy (14). The gene discussed is METTL3; the disease is non-small cell lung carcinoma.