ALDH1A1 and cholangiocarcinoma: The “stem-like” CCA is characterized by an overexpression of genes connected to stemness, an increase in the glycolysis pathway and ALDH1A1 overexpression and patients have an intermediate prognosis Therefore, a combination treatment consisting of an ALDH1A1 inhibitor and nab-paclitaxel had a synergic effect in ALDH1A1+ organoids but presented an antagonist effect in the ALDH1A1- organoids (201).