These rankings are biologically coherent: elevated PLR and MLR—and, to a lesser extent, NLR—capture platelet- and monocyte-driven inflammatory signaling that accompanies deeper muscular invasion (T2), whereas increases in CA19–9 and CA125 reflect biliary stasis or serosal irritation that become more pronounced once the tumor breaches the lamina propria. Here, MUC16 is linked to neoplasm.