Most polyamine metabolism genes (ATP13A2, AZIN1, AZIN2, OAZ1, OAZ2, OAZ3, AOC1, PAOX, SAT1, SMOX, SRM, SMS, and AGMAT) were highly expressed in BC In contrast, AMD1, ODC1, SAT2, and ARG1 showed lower expression in cancer tissues (Figure 2A). The gene discussed is ATP13A2; the disease is breast cancer.