CXCL12 and ovarian cancer: Moreover, it is known that this pathway plays a key role in ovarian cancer pathogenesis by regulating many of the mechanisms involved (such as cell survival, growth, proliferation, angiogenesis, and metabolism).In rodents, it was shown that another chemokine/chemokine receptor system (CXCR4/SDF1) is involved in the follicle activation process, where an inhibitory role of the latter was observed in the primordial-to-primary transition (15), opposite to our present results.