Low-intensity pulsed ultrasound-induced calcium influx promotes the beneficial effects of angiogenesis, improved renal function, and Akt-eNOS phosphorylation in rats with acute kidney injury through the Notch1-Akt-eNOS signaling pathway, making Notch1 activation a therapeutic strategy for acute kidney injury targeting angiogenesis (39). This evidence concerns the gene AKT1 and acute kidney injury.