SMAD3 and renal fibrosis: By interfering with the JNK/Notch-2 signaling pathway, TSA shows potential therapeutic effect in the treatment of renal fibrosis (–).-Epigallocatechin gallate (EGCG), as a natural antioxidant, can inhibit the expression of Notch1 and reduce the activation of the TGF-β/Smad3 signaling pathway, thereby alleviating renal fibrosis in diabetic mice (88).