In the multivariate logistic regression analysis, which included IL-6, CRP, ESSPRI total, ESSPRI pain, ESSPRI fatigue, and ESSDAI, only ESSPRI fatigue was identified as an independent predictor of anxiety (OR = 1.99, 95%CI: 1.12-3.53, P = 0.019; Table 3). The gene discussed is CRP; the disease is Anxiety.