REN and hypertensive disorder: Additionally, suppression of renin expression by vitamin - D is independent of its role in calcium metabolism and instead, it islinked to the body's regulation of sodium balance and angiotensin II feedback mechanisms [12].This finding is corroborated by Li et al. [13] who demonstrated that vitamin - Dreceptor knockout mice exhibited higher renin levels, leading to increased angiotensin II and the development of hypertension andcardiac hypertrophy [7].