MARCO and Alzheimer disease: In the AD control mice, scavenger receptors were upregulated in response to Aβ deposition, as indicated by increased levels of CD68 (*P = 0.028), MARCO (*P = 0.023), and SRA (***P < 0.001) in the hippocampus, as well as increased levels of CD68 (*P = 0.021) and SRA (**P = 0.004) in the frontal cortex (Figures 1A,B).