This may suggest enhanced microglial phagocytic activity, as SRA and RAGE play key roles in microglial phagocytosis and activation by binding to ligands such as β-amyloid (Aβ) and advanced glycation end products, thereby contributing to the pathogenesis of brain diseases like AD (Wilkinson and El Khoury, 2012). The gene discussed is AGER; the disease is brain disorder.