This may suggest enhanced microglial phagocytic activity, as SRA and RAGE play key roles in microglial phagocytosis and activation by binding to ligands such as β-amyloid (Aβ) and advanced glycation end products, thereby contributing to the pathogenesis of brain diseases like AD (Wilkinson and El Khoury, 2012). This evidence concerns the gene AGER and Alzheimer disease.