STOX2 and glioblastoma: The SNPs associated (p = 8.28 × 10−12) with BRD is within an intron of STOX2. Chen et al. (74) reported that the downregulation of STOX2 in glioblastoma stem-like cells leads to apoptosis, but the upregulation of STOX2 in these cells increased the expression of immune suppressing ligands.