Novel synthetic antifungal compounds, such as isavuconazole, possess distinct structures that interact with lanosterol 14α-demethylase and inhibit the expression of efflux pumps in C. auris. Fosmanogepix treats candidemia by inhibiting the Gwt1 enzyme, thereby disrupting the transport of mannoproteins within the fungal cell wall and membrane. Here, PIGW is linked to Candidemia.