Streptococcus receptor polysaccharides may stimulate aortic endothelial cells, and cytokines (IL-6, IL-8, and monocyte chemoattractant protein-1) and intercellular adhesion molecule-1 showed increased expression, thus contributing to cardiovascular disease progression and arterial thrombosis (de Toledo et al., 2012). The gene discussed is ICAM1; the disease is Arterial thrombosis.