The study included 481 patients (55.7% women), their ages, 31.79 ± 9.31 years, 43.9% had previously been diagnosed with obesity, 28.4%, and 30.7% were on regular exercise and a healthy diet respectively, while 21.8% were using glucagon-like peptide-1 receptors agonists (GLP-1 agonists), 11.2% conducted bariatric surgery (some patients used > one obesity management). The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.