In addition, a study carried out on patients treated with CIP demonstrated an increase in oxidative stress in plasma after 5 days of treatment, manifesting a significant increase of lipid peroxides and a decrease in the antioxidant status, the antioxidant enzyme superoxide dismutase (SOD) and GSH (Talla and Veerareddy, 2011). This evidence concerns the gene SOD1 and hereditary sensory and autonomic neuropathy.