FGF2 and Hepatic fibrosis: Cynaroside blocked the activation and development of liver fibrosis by inhibiting the overexpression of FGFR2 and the excess of basic fibroblast growth factor (bFGF), thus reducing hepatic stellate cell (HSC) activation and collagen secretion in hepatocytes (Sato-Matsubara et al., 2017; Wang et al., 2020).