We presented a case of a patient with advanced intrahepatic cholangiocarcinoma (iCCA) harboring dual somatic homologous recombination repair (HRR) gene pathogenic variants, specifically BRCA1 and PALB2, who achieved PR lasting approximately 7 months following salvage treatment with olaparib. The gene discussed is PALB2; the disease is intrahepatic cholangiocarcinoma.