PPARG and acute lymphoblastic leukemia: Only several researchers have shown that DIM is a potential compound for therapeutic application in human T-ALL cells (Shorey et al., 2012) and that a ring-substituted diindolylmethane derivative (DIM #34), 1,1-bis [3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, selectively induced apoptosis in AML cells through regulation of the extracellular signal-regulated kinase and the PPAR gamma-dependent signaling pathways (Contractor et al., 2005).