AHR and cancer: DIM has also shown great potential for anti-proliferative and anti-inflammatory activities in several types of cancers, involving NF-κB, Akt, Wnt, PI3K/Akt/mTOR, and AhR signaling (Biersack, 2020; Reyes-Hernández et al., 2023), and several synthetic derivatives of DIM with increased bioavailability have been used as active antitumor compounds (Biersack, 2020).