Algal polysaccharide can treat osteoporosis by inducing and enhancing Akt/TFEB pathway-dependent autophagic flow and alleviate osteoblast pyroptosis by promoting osteoblast autophagy. In addition, Algal polysaccharide can reduce osteoclast-mediated osteoclastogenesis by promoting autophagosome formation, increasing ERK phosphorylation in osteoblasts, and upregulating OPG secretion. This evidence concerns the gene TFEB and osteoporosis.