Although there are some limitations in this research, such as the effect of tumor burden on circTNPO3 expression level could not be assessed due to the lack of preoperative and postoperative serum samples, and the absence of transgenic animal models also made it difficult to fully simulate the effects of circTNPO3 on the occurrence of PC in vitro, the circTNPO3/miR-188-5p/CDCA3/TRAF2/NF-κB axis in PC occurrence and progression is first reported, and still possesses theoretical significance. The gene discussed is CDCA3; the disease is pachyonychia congenita.