Combining the clinicopathologic data from TCGA and TNMplot, and the IHC analysis from 74 patients, it was showed that the expression level of CDCA3 was aberrantly elevated in PC tumor tissues compared with that in the adjacent peritumoral tissues, and was negatively associated with patient survival (Figures 8D–H). The gene discussed is CDCA3; the disease is pachyonychia congenita.