More importantly, in order to further clarify that circTNPO3 ultimately regulated the malignant biological characteristics and chemoresistance of PC through NF-κB signaling pathway, the overexpression or silence of circTNPO3 was performed in the parental non-resistant BxPC-3 cells and resistant BxPC-3/GR cells. The gene discussed is NFKB1; the disease is pachyonychia congenita.