For example, in hepatocellular carcinoma, circTNPO3 regulates STRN expression through competitively sponging miR-199b-5p to promote cell proliferation, migration and invasion, meanwhile, inhibit cell apoptosis (Liu and Liu, 2023); In ovarian cancer, circTNPO3 facilitates paclitaxel resistance via ceRNA mechanism which could be described as absorbing miR-1299 and interfering with the downstream NEK2 (Xia et al., 2020). The gene discussed is STRN; the disease is hepatocellular carcinoma.