The Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome, which is composed of NLRP3 protein, Apoptosis-associated Speck-like protein containing a CARD (ASC), and caspase-1, serves as a principal mediator of inflammation associated with CKD, wherein activated NLRP3 inflammasomes facilitate the production and secretion of mature pro-inflammatory cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18) (Yuan et al., 2022). The gene discussed is CASP1; the disease is chronic kidney disease.