Treatment with MCC950 (10 mg/kg), US + MCC950 (5 mg/kg), and US + MBs + MCC950 (5 mg/kg) significantly reduced serum creatinine, blood urea nitrogen, and albumin-to-creatinine ratios, and alleviated kidney damage and fibrosis compared to untreated CKD rats. This evidence concerns the gene ALB and chronic kidney disease.