Notably, in silico studies demonstrated strong binding affinities of these compounds to SARS-CoV-2 targets, including the spike protein, spike protein-angiotensin-converting enzyme 2 (ACE-2) receptor complex, main protease (Mpro), papain-like protease (PLpro), RNA-dependent RNA polymerase (RdRp), and N-protein RNA-binding domain, supporting their proposed role in COVID-19 management. Here, ACE2 is linked to COVID-19.