Moreover, KO exhibited potent anti-inflammatory activity, suppressing tumor necrosis factor-α (TNF-α) secretion in both lipopolysaccharide (LPS)-stimulated human acute monocytic leukemia cells (THP-1) and rat peritoneal macrophages, with consistent efficacy in mice inflammation models (Bonaterra et al., 2017; Vigerust et al., 2013; Zadeh-Ardabili and Rad, 2019). The gene discussed is TNF; the disease is acute monocytic leukemia.