APP/PS1 mice display anxiety-like behavior, which is generally considered a depressive tendency induced by underlying AD pathology; in an unfamiliar environment, anxious APP/PS1 mice tend to stay in the corners, so their level of activity in the central area can reflect both the severity of their emotional disturbance and any improvement (Johansson et al., 2020). This evidence concerns the gene PSEN1 and Alzheimer disease.