MAPT and Alzheimer disease: This enables the mice to mimic several clinical and pathological features of AD, including Aβ deposition, inflammatory cytokine responses, Tau protein hyperphosphorylation, neurofibrillary tangles, and neuronal loss, with these pathological changes worsening with age and ultimately leading to cognitive impairment (Jankowsky et al., 2004; Long et al., 2021; Mifflin et al., 2021).