BMAL1 and obesity due to melanocortin 4 receptor deficiency: Furthermore, female IEC-Bmal1−/− mice treated with 16 weeks of 60% high-fat diet were significantly more resistant to diet-induced obesity (reduced weight gain) compared with Bmal1flox mice, in keeping with recently published data9 (Figures S2D and S2E), supporting the successful induction of IEC-specific Bmal1 deletion.