ITIH4 and infection: Nine male, adult RMs randomly divided into three groups (3 per group) were immunized with sequential clade C HIV-1 CH505 Env gp120 proteins (CH505 TF, CH505wk53, CH505wk78, and CH505wk100) that were originally isolated from a person recruited into the CHAVI 001 cohort about 4 weeks after infection and who was followed for over three years8,33,34 (Figure 1A).