Notably, our study found that CLL patients with worse prognostic factors, that is, high expression of ZAP-70 and CD38, had classical monocytes with high expression of miR-106a-5p, suggesting that this oncomiR may be one of the key regulators influencing the attenuation of antitumor activity of these cells, thus promoting disease progression. This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.