Notably, our study found that CLL patients with worse prognostic factors, that is, high expression of ZAP-70 and CD38, had classical monocytes with high expression of miR-106a-5p, suggesting that this oncomiR may be one of the key regulators influencing the attenuation of antitumor activity of these cells, thus promoting disease progression. The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.