Moreover, we observed a significantly higher expression of miR-106a-5p in classical monocytes from ZAP-70+ compared to ZAP-70− CLL patients (median, IQR; 1.47, 2.05–1.04 vs. 0.59, 0.81–0.18; p=0.0286) and in CD38+ CLL patients compared to CD38− CLL patients (median, IQR; 1.8, 2.14–1.14 vs. 0.6, 0.95–0.315; p=0.0357) (Figure 12(a)). This evidence concerns the gene ZAP70 and B-cell chronic lymphocytic leukemia.