Our studies have shown that MLR-high CLL patients have a reduced percentage of classical monocytes with intracellular TNF expression with significantly elevated miR-106a-5p expression, suggesting that miR-106a-5p may affect the dysfunction of classical monocytes responsible for monocytosis by regulating the ability of these cells to secrete TNF. Here, TNF is linked to B-cell chronic lymphocytic leukemia.