As a part of the pathway involved in extracellular matrix-receptor interactions, ITGB1 exhibits a remarkable increase in expression in HPV-related head and neck cancer (HNC), cervical cancer (CC), and patients with OCSCC (Kwon et al., 2022; Lv et al., 2024; Park et al., 2023). This evidence concerns the gene ITGB1 and head and neck cancer.