Compared with the GnRH-a regimen, the GnRH-A regimen exhibits advantages such as short treatment time, low gonadotropin (Gn) dosage, flexible medication, rapid inhibition of luteinizing hormone (LH) peak, and low incidence of ovarian hyper-stimulation syndrome (OHSS). The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.