The relative expression levels of IL1B and CXCL8, two major proinflammatory cytokines involved in RPE inflammation, were increased by 14.4-fold and 12.1-fold, respectively, as shown in Fig. 1E. C–C motif chemokine 5 (CCL5), which has been reported as an AMD-related chemokine [14], was upregulated by 37,122-fold as a result of the reduction of HNRNPA1 (Fig. 1E). The gene discussed is CXCL8; the disease is age-related macular degeneration.