In esophageal squamous cell carcinoma (ESCC), Piezo1 upregulation activates the p53–Bax–Caspase-3 apoptosis pathway to resist apoptosis, while knockdown of Piezo1 reactivates this pathway and blocks the G0/G1→S transition, exhibiting a function as an “anti-apoptotic switch” (68, 82). The gene discussed is CASP3; the disease is esophageal squamous cell carcinoma.