Upon activation, Piezo1 triggers Ca2+ influx and massive extracellular ATP release, thereby enhancing pseudopodium formation, migration, and invasion; conversely, Piezo1 silencing or blockade sharply suppresses these phenotypes, whereas the selective agonist Yoda1 can “re-ignite” the invasive program—implicating a Piezo1–ATP–positive-feedback loop as a key mechanical driver of cervical-cancer metastasis (71). The gene discussed is PIEZO1; the disease is cervical cancer.