In high-stiffness tumors such as glioblastoma, excessive activation of Piezo1 synergizes with the integrin–focal adhesion kinase (FAK) signaling axis, forming a positive feedback loop—”increased stiffness → enhanced Piezo1 currents → FAK activation → collagen redeposition → further stiffness elevation”—which correlates with reduced patient survival (84). This evidence concerns the gene PTK2 and glioblastoma.