PIEZO1 and digestive system neoplasm: Digestive-system tumors: In digestive and associated glandular malignancies, mechanosensitive ion channel Piezo1 is broadly upregulated and significantly associated with invasive phenotypes and poor prognosis; however, its oncogenic mechanisms show marked tissue-specific downstream pathway divergence, reflecting the biological feature of “homologous channel–divergent outputs.” In gastric cancer, the expression of Piezo1 is significantly elevated in most cell lines and primary samples.