Transcriptomic analysis further identified Piezo1 as a direct transcriptional target of YAP upon upregulation, YAP induces Piezo1, leading to Ca2+ influx and amplification of proliferative signaling, while inhibition of YAP or knockdown of Piezo1 significantly suppresses tumor cell growth in 2D, 3D, and suspension cultures. The gene discussed is PIEZO1; the disease is neoplasm.