PEMT and colorectal cancer: Recent evidence using several public datasets from The Cancer Genome Atlas (TCGA), Kyoyo Encyclopedia of Genes and Genomes (KEGG), AmiGO (2) and Reactome Pathways databases has identified two choline metabolism-related genes (choline kinase β, CHKB, and phosphatidylethanolamine N-methyltransferase, PEMT) as key genes involved in the pathogenesis of human colorectal cancer (220, 221).