IGHE and asthma: However, in another study asthma patients (ages 15-45) receiving oral choline supplementation (1500 mg b.i.d.)with inhaled steroids (Budesonide; 400 μg twice daily) and long-acting β-agonist (LABA; formoterol fumarate; 6 μg twice daily) for six months (94), required less additional therapy and had improved bronchial hyperreactivity with a reduction in eosinophil count and total IgE, IL-4, IL-5, TNF-α, and airway inflammatory lipid mediators such as Cys-LT, LTb4 and 8-isoprostanes with no significant changes in IL-10 and IFN-γ, compared to the group with standard pharmacotherpay alone (94).