ITGAM and graft versus host disease: Indeed, in a model of graft-versus-host disease (GVHD), T-cell-depleted bone marrow transplants fed with TMAO-rich diet exhibited a significant increase in the frequency of F4/80+CD11b+CD16/32+ inflammatory macrophages relative to the F4/80+CD11b+ whole population, worsening disease severity, and increasing mortality (80).