In female patients with SLE, the increase of 168 mg choline per day was associated with a 10% higher methylation of CD40L promoter (198), Besides these findings, it has not been evaluated whether different forms of dietary choline can modify disease progression or the frequency of flares in SLE patients, neither if the selective inhibition of ACh signaling in B cells can prevent autoreactivity and the severity of organ-specific manifestations. Here, CD40LG is linked to systemic lupus erythematosus.