Our findings demonstrate that IL-18 and MMP-9 are consistently associated with cognitive impairment across both the 3- to 30-month (PSCI) and 7- to 30-month (dPSCI) follow-up periods, MIP-1α is associated with cognitive impairment during the 3- to 30-month period, and IL-8 during the 7- to 30-month period. This evidence concerns the gene CXCL8 and Cognitive impairment.