Despite advances in targeted therapies (e.g., BRAF/MEK inhibitors) (24, 25) and immunotherapies (e.g., anti-PD-1/PD-L1/CTLA-4) (26, 27), clinical outcomes remain variable, particularly in metastatic disease, where 5-year survival rates drop below 30%. The gene discussed is BRAF; the disease is metastatic neoplasm.