Functionally, pathway enrichment analysis revealed that high SUMOylation activity correlated with enhanced signaling in proliferation, metabolism, and cell cycle-related pathways, particularly the G2M_CHECKPOINT, E2F_TARGETS, and MYC_TARGETS V1/V2 pathways (Figure 3A), suggesting that SRGs may facilitate tumor progression by promoting cell growth and metabolic activity. Here, MYC is linked to neoplasm.