These findings are consistent with previous reports of L3MBTL2 acting as a metastasis suppressor through chromatin remodeling (75–77), as well as VHL functioning as a negative regulator of angiogenesis via HIF-1α degradation (78, 79) Our results therefore provide in vitro evidence supporting their tumor-suppressive roles in STAD. This evidence concerns the gene VHL and gastric adenocarcinoma.