Since activated NF-κB protein can transcriptionally regulate CCND1 by directly binding to its promoter (48), and CCND1 also serves as a target gene for STAT3 (49), we believed that APMAP interfered the proliferation ability of ESCC cells by modulating the expression of CCND1, and at least in part, through the regulation of the NF-κB pathway. The gene discussed is CCND1; the disease is esophageal squamous cell carcinoma.