HMGB1 and neoplasm: It is worth noting that cyclophosphamide and carboplatin have been proven to be more cytotoxic to Treg cells than to Teff cells (160, 161).Furthermore, chemotherapeutic agents induce tumor cell death and promote the release of DAMPs, including adenosine triphosphate, high-mobility group box 1 (HMGB1), and type 1 IFN (IFN-I).