ICAM1 and Thrombocytopenia: IL-1, IL-6, platelet-activating factor (PAF), intercellular adhesion molecule 1 (ICAM-1), P-selectin and vWF released by endothelial cells are all powerful activators of platelets that increase the binding of platelets to endothelial cells, thereby further inducing platelet activation and aggregation and leading to a progressively stronger effect; this mechanism may even induce DIC and thrombocytopenia.