PI3Kγ inhibition in TAMs led to increased production of pro-inflammatory cytokines, enhanced CD8+ T cell cytotoxicity, and suppressed tumor growth in mouse models of cancers including pancreatic ductal adenocarcinoma, lung adenocarcinoma and colon cancer, attributing to the activation of NF-κB and suppression of C/EBPβ signaling pathways in TAMs (79). The gene discussed is CD8A; the disease is neoplasm.