NR1H4 and colorectal cancer: In a colorectal cancer (CRC) lung metastasis model, gut dysbiosis-induced TCA accumulation promoted M-MDSC expansion and immunosuppressive function by enhancing glycolysis and epigenetically stabilizing PD-L1 expression via H3K4 mono-methylation, with potential involvement of the Farnesoid X Receptor (FXR) (48).