(2023) showed that bile salt hydrolase (BSH) activity in non-enterotoxigenic Bacteroides potentiated colorectal cancer (CRC) by increasing colonic deoxycholic acid (DCA) and lithocholic acid (LCA), which activated tumor cell TGR5, upregulated CCL28, and promoted immunosuppressive Treg infiltration. Here, GPBAR1 is linked to colorectal cancer.