Furthermore, in patients with HCV-related chronic liver disease, levels of taurine-conjugated BAs strongly correlated with increased hepatic S1PR2 expression, markers of inflammation (NLRP3 inflammasome, NF-κB pathway genes), and liver disease severity, suggesting a pathological role for the Tau-BA-S1PR2 axis in hepatic inflammation (104). The gene discussed is S1PR2; the disease is liver disorder.