A differential expression (DE) analysis (with sex and age as covariates; p adj.<0.05) found no significantly different genes when comparing pre- and post-samples (not shown) while tumor subtype comparisons found significant transcripts upregulated in LUAD EVs, like ERAP2, mirroring the NK cell transcriptomic signature (Figure 2f). This evidence concerns the gene ERAP2 and neoplasm.